Sayana Press (medroxyprogesterone acetate) patient support website.

  • How does Sayana Press work?
  • How effective is Sayana Press?
  • Is it okay to breastfeed and take Sayana Press?
  • I’ve just had a baby, how soon can I start Sayana Press?
  • Who should not take Sayana Press?
  • Can Sayana Press change my periods?
  • I’m worried about gaining weight, what can I expect?
  • I missed an injection or my injection appointment, what should I do?
  • Will I get any skin reactions to Sayana Press?
  • Is there an increased risk of cancer?
  • Does Sayana Press have an effect on bone health?
  • Does Sayana Press have an effect on bone health in teenagers (up to 18 years)?
  • What if I don’t want to continue Sayana Press?
  • Can my Sayana Press expire?
  • What temperature should I store Sayana Press?
  • Does Sayana Press cause blood clots?
  • Does Sayana Press protect against sexually transmitted infections?
  • What if I decide to have a family?
  • Can I continue Sayana Press for more than 2 years?

Like all medicines, Sayana Press can cause side effects, please see the Patient Information Leaflet for more information

Please familiarise yourself with this section and re-read it regularly.

Talk to your doctor, pharmacist or nurse before using SAYANA PRESS.

Before your doctor prescribes SAYANA PRESS, you may need to have a physical examination. It is important to tell your doctor if you have, or have had in the past, any of the following conditions. Your doctor will then discuss with you whether SAYANA PRESS is suitable for you.

Tell your doctor if you have:

  • Migraine headaches
  • Diabetes or a family history of diabetes
  • Severe pain or swelling in the calf (indicating a possible clot in the leg, which may be called phlebitis)
  • A blood clot in the lung (pulmonary embolism)
  • A blood clot in your eye affecting your vision (retinal thrombosis)
  • A history of heart disease or cholesterol problems including any family history
  • Past history of depression
  • Irregular, light, or heavy menstrual periods
  • An unusual breast x-ray, fibrocystic breast disease, breast nodules or lumps, or bleeding from your nipples
  • A stroke
  • Family history of breast cancer
  • Kidney disease
  • High blood pressure
  • Asthma
  • Epilepsy
  • Psychiatric disorders - Some women using hormonal contraceptives including SAYANA PRESS have reported depression or depressed mood. Depression can be serious and may sometimes lead to suicidal thoughts. If you experience mood changes and depressive symptoms contact your doctor for further medical advice as soon as possible.
  • Bone health, blood clots and possible risk of cancer - for information about effects on these areas, please see the ‘While on Sayana’ section and/or read the Patient Information Leaflet.

The Sayana Press Patient Information Leaflet is available at this link:

If you think you have experienced a side effect from your medicine, you should report it to the MHRA through the Yellow Card Scheme. You should also contact Pfizer medical information on 01304 616161